柴纬明

柴纬明  理学博士

副教授（校聘教授），硕士生导师（植物资源学专业），江西省农业科技特派员

● 学习、工作经历：

2014.06至今 江西师范大学生命科学学院讲师、副教授、校聘教授

2009.09—2014.06 厦门大学博士（硕博连读）

2005.09—2009.07 江西师范大学学士（本科）

● 研究兴趣、领域：

植物资源学和天然产物化学（植物天然产物活性成分分析和开发）、食品科学与分子酶学、有机小分子合成及活性筛选、生态学、细胞生物学。

● 开设的课程：

本科生课程：《植物生物学》、《植物生物学实验》

研究生课程：《植物成分分析》、《植物科学研究进展》

● 代表性论文：

1.Huang, Q., Chai, W. M.,^* Ma, Z. Y., Ou-Yang, C., Wei, Q. M., Song, S., ... & Peng, Y. Y. (2019). Inhibition of α-glucosidase activity and non-enzymatic glycation by tannic acid: Inhibitory activity and molecular mechanism. International journal of biological macromolecules,141，358-368. (SCI二区，IF=4.784)

2.Chai, W., Ou-Yang, C., Ma, Z., Song, S., Huang, Q., Wei, Q., & Peng, Y. (2019). Anti-α-glucosidase and antityrosinase activity of condensed tannins from the bark of Clausena lansium (Lour.) Skeels with antiproliferative and apoptotic properties in B16 mouse melanoma cells. Process Biochemistry. (SCI三区，IF=2.883)

3.Chai, W. M. ,^*Wei, Q., Deng, W., Zheng, Y. , Chen, X., Huang, Q., Ou-Yang, C. and Peng, Y. Y. (2019). Anti-melanogenesis property of condensed tannins from Vigna angularis seed with potent antioxidant and DNA damage protection activities. Food function, 10(1), 99-111. (SCI一区，IF= 3.241)

4.Lin, M. Z., Chai, W. M.,^* Zheng, Y. L., Huang, Q., Ou-Yang, C. (2019). Inhibitory kinetics and mechanism of rifampicin on α-glucosidase: Insights from spectroscopic and molecular docking analyses. International journal of biological macromolecules,122,1244-1252. (SCI二区，IF=4.784)

5.Chai, W. M.,^* Huang, Q., Lin, M. Z., Ou-Yang, C., Huang, W. Y., Wang, Y. X., Xu, K. L., Feng, H. L. (2018). Condensed tannins from longan bark as inhibitor of tyrosinase: structure, activity, and mechanism. Journal of agricultural and food chemistry, 66(4), 908-917. (SCI一区，IF=3.571)

6.Chai, W. M.,^*Ou-Yang, C., Huang, Q., Lin, M. Z., Wang, Y. X., Xu, K. L., (2018). Huang, W. Y., Pan, D. D. Antityrosinase and antioxidant properties of mung bean seed proanthocyanidins: Novel insights into the inhibitory mechanism. Food chemistry, 260, 27–36. (SCI二区TOP，IF=5.399)

7.Lin, M. Z., Chai, W. M.,^* Ou-Yang, C., Huang, Q., Xu, X. H., Peng, Y. Y. (2018). Antityrosinase mechanism of omeprazole and its application on the preservation of fresh-cut Fuji apple. International journal of biological macromolecules,117, 538-545. (SCI二区，IF=4.784)

8.Chai, W. M.,^* Lin, M. Z., Feng, H. L., Zou, Z. R., Wang, Y. X. (2017). Proanthocyanidins purified from fruit pericarp of Clausena lansium (Lour.) Skeels as efficient tyrosinase inhibitors: structure evaluation, inhibitory activity and molecular mechanism. Food function,8, 1043-1051. (SCI一区，IF= 3.241)

9.Chai, W. M.,^* Lin, M. Z., Wang, Y. X., Xu, K. L., Huang, W. Y., Pan, D. D., Zou Z R, & Peng, Y. Y. (2017). Inhibition of tyrosinase by cherimoya pericarp proanthocyanidins: Structural characterization, inhibitory activity and mechanism. Food research international, 100, 731-739. (SCI二区，IF=3.579)

10.Chai, W. M.,^* Lin, M. Z., Song, F. J., Wang, Y. X., Xu, K. L., Huang, J. X., Fu, J. P., & Peng, Y. Y. (2017). Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism. International journal of biological macromolecules, 102, 425-430. (SCI二区，IF=4.784)

11.Wang, R., Chai, W. M.,^* Yang, Q., Wei, M. K., Peng, Y. Y. (2016). 2-(4-Fluorophenyl)-quinazolin-4 (3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism. Bioorganic & medicinal chemistry, 24(19), 4620-4625. (IF=2.9)

12.Wei, M. K., Chai W M,^* Wang, R., Yang, Q., Deng, Z., Peng, Y. Y. (2016). Quinazolinone derivatives: synthesis and comparison of inhibitory mechanisms on α-glucosidase. Bioorganic & medicinal chemistry. 25(4), 1303–1308 (IF=2.9)

13.Chai, W. M.,^* Wei, M. K., Wang, R., Deng, R. G., Zou, Z. R., Peng, Y. Y. (2015). Avocado proanthocyanidins as source of tyrosinase inhibitors: structure characterization, inhibitory activity and mechanism. Journal of agricultural and food chemistry,63 (33), 7381–7387. (SCI一区，IF=3.571)

14.Chai, W. M., Shi, Y, Feng, H. L., Xu, L., Xiang, Z. H., Gao, Y. S., Chen, Q. X.^*(2014). Structure characterization and anti-tyrosinase mechanism of polymeric proanthocyanidins fractionated from kiwifruit pericarp. Journal of agricultural and food chemistry,62(27), 6382-6389. (SCI一区，IF=3.571)

15.Chai, W. M., Chen, C. M., Gao, Y. S., Feng, H. L., Ding, Y. M., Shi, Y., Zhou, H. T., Chen, Q. X.^*(2014). Structural analysis of proanthocyanidins isolated from fruit stone of Chinese hawthorn with potent antityrosinase and antioxidant activity. Journal of agricultural and food chemistry, 62(1), 123–129. (SCI一区，IF=3.571)

16.Chai, W. M., Liu, X.,Hu, Y. H., Feng, H. L., Jia, Y. L., Guo, Y. J., Zhou, H. T.^*, Chen, Q. X.^* (2013). Antityrosinase and antimicrobial activities of furfuryl alcohol, furfural and furoic acid. International journal of biological macromolecules, 57, 151-155. (SCI二区，IF=4.784)

17.Chai, W. M., Shi, Y., Feng, H. L., Qiu, L., Zhou, H. C., Deng, Z. W., Yan, C. L.^*, Chen, Q. X.^*(2012). NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from Delonix regia and their bioactivities. Journal of agricultural and food chemistry, 60 (19), 5013-5022. (SCI一区，IF=3.57)

● 科学研究：

①科研项目：

国家自然科学基金地区项目：多酚类化合物抗果蔬酶促褐变及抗菌机制研究 主持

国家自然科学基金青年项目：龙眼（Dimocarpus longanLour.）单宁分离鉴定与抗酪氨酸酶机理研究 主持

江西省自然科学基金青年重点项目：MALDI-TOF MS和UPLC-MS/MS指导分离壳斗科植物单宁（tannins）及其抗酪氨酸酶机制研究 主持

江西省自然科学基金青年项目：黄皮原花色素分离纯化、结构分析与抗α－葡萄糖苷酶机制研究 主持

③参与“973”前期研究专项“东南沿海防护林功能维持与演变的基础研究” 、红树植物单宁结构与抗氧化活性及其对生态系统营养循环的效应、血浆蛋白质在髓过氧化物酶生物降解单壁碳纳米管中影响机制的研究、纤维素酶的活性和产物耐受性协同进化机制研究、加拿大一枝黄花中灭螺活性成分的发及其作用机制研究、樟属植物芳樟龙脑樟精油微胶囊化制备及其对镰刀菌的抑制机理研究等多项国家级课题的研究工作和一项省自然科学基金“红树植物多酚结构与抑制多酚氧化酶机理研究”的研究工作。

④指导研究生获国家奖学金6人次，江西省省政府奖学金3人次;指导研究生获江西省特优毕业论文。

●教学研究：

主持江西省省级教学改革课题2项--【《植物学》中“思政元素”的发掘及课程思政教育实践；《植物成分分析》中“思政元素”的发掘及课程思政教育实践】、江西省基础教育研究课题1项--【基于高校实验资源拓展高中生物实验教学的初探】。完成江西师范大学校级教学改革课题1项--【生物学专业在线开放学位课程建设的探索与实践— 以《植物成分分析》为例】。发表教学改革论文 3 篇。

● 荣誉、奖励及参加学术团体的情况：

获厦门市科技进步二等奖、福建省优秀论文三等奖

指导挑战杯省二等奖、指导全国生命科学大赛优胜奖

中国生物化学与分子生物学会会员

江西省植物学会会员

● 联系方式：

地址：生命科学学院方荫楼3区W351室

Email: chaiweiming@jxnu.edu.cn

QQ: 476239387